1. The First Hokage's Power: The First Hokage was able to capture and distribute the nine tailed beasts among the five great nations alone, showcasing his power compared to the Akatsuki. His ultimate move, the Wood Release: Thousand Hands, created a massive Buddha statue that could grab tailed beasts with a single hand.

2. Uchiha Madara's Power: Madara, the lifelong nemesis of the First Hokage, is equally powerful.

His evil power allows him to summon meteors and use the Susanoo technique with tailed beast integration, matching the power of Hashirama's Thousand Hands. Madara can easily defeat the Akatsuki using meteors or Susanoo.

3. Second Hokage Tobirama's Power: Tobirama, the younger brother of the First Hokage, created a peaceful period alongside Hashirama. His powerful water release and unique forbidden jutsu, such as the Reanimation Jutsu, could annihilate the Akatsuki by summoning deceased powerful shinobi.

4. Kushina Uzumaki's Power: Kushina, the wife of the First Hokage and ancestor of Naruto, possesses the scariest power of the Uzumaki clan - sealing jutsu. As a perfect jinchuriki, she could control the Nine-Tails' power without fear. Even Pain couldn't defeat a jinchuriki with five tails, making Kushina a formidable opponent for the Akatsuki.

5. Sage of the Six Paths' Power: The Sage of the Six Paths, ancestor of all ninja, possesses the Rinnegan, a power respected by the nine tailed beasts. Even the First and Second Hokage pale in comparison to him. The Akatsuki would stand no chance against the ultimate power of the Sage of the Six Paths.