1. Orochimaru: Orochimaru, also known as "Snake-san," is an expert at creating artificial humans. He developed a technique to transfer his soul into a new body for immortality. Orochimaru's body has been extensively modified, making him an artificial human. His research has allowed him to achieve eternal life, surpassing even the Sage of the Six Paths.

2. Scorpion of the Red Sand: Scorpion is a member of the Akatsuki and the most skilled puppet jutsu user in Naruto.

Similar to Orochimaru, he achieves immortality by transferring his life force to puppets. Through self-modification, Scorpion has become immortal.

3. Mitsuki: Orochimaru created Mitsuki using his own cells. Mitsuki inherited Orochimaru's genes, allowing him to use snake ninja techniques and Sage jutsu. The Seal of Sage Chakra was implanted in Mitsuki's heart.

4. Pain's Six Paths: Controlled by Nagato, the Six Paths are powered by chakra-absorbing rods. They are more like chakra-driven robots and can be remade as long as Nagato is alive.

5. Yamato: Unlike others with transplanted cells, Yamato underwent extensive modifications by Orochimaru. His body assimilated with Hashirama cells, making him a true artificial human.