1. Six Paths Sage Toad Gama-chan: Gama-chan in the Six Paths Sage era was the first toad to master natural energy, passing down his knowledge to the many toads in Mount Myoboku. He taught the Six Paths Sage ninjutsu and how to control natural energy, making him the first to perfectly use toad-style ninjutsu.

2. Jiraiya: As one of the Legendary Sannin, Jiraiya learned Sage Mode under the guidance of Fukasaku.

Combining it with two toad sages, he can maintain the mode without time limitations.

3. Minato Namikaze: Minato, Jiraiya's disciple, used Sage Mode to fight Madara Uchiha but lacked expertise due to his duties as the Fourth Hokage. Nonetheless, his talent suggests he could master any jutsu given enough training.

4. Naruto: Naruto's Sage Mode is believed to surpass Jiraiya and Minato's because of its shorter activation time and minimal appearance change.

However, Naruto's duration is limited compared to Jiraiya, who combines with the toad sages to eliminate time limitations.

5. Moegi: In Naruto, inheritance is emphasized, seen in the passing down of legacies. Naruto will guide Moegi to learn senjutsu to continue Mount Myoboku's techniques. Fans believe Moegi is worthy of syncing with Enma, but Naruto tricks her into syncing with a toad. As long as it helps Moegi gain an advantage in battle, it is useful.