NO.1 Kakashi Hatake: Kakashi is known for receiving the Sharingan from Obito during the Third Great Ninja War. He became a renowned ninja and posed a threat to Kaguya in the Fourth Great Ninja War.

NO.2 Sasuke Uchiha: Sasuke had the Mangekyou Sharingan even before obtaining the powers of the Sage of Six Paths. During the Fourth Great Ninja War, he gained the Rinnegan while retaining the Mangekyou Sharingan.

NO.3 Obito Uchiha: Obito witnessed Kakashi killing Rin and turned to the dark side. He utilized Nagato and manipulated the Akatsuki. Obito's eyes became a combination of Sharingan and Rinnegan.

NO.4 Ao: Ao, an elite Jonin from Kirigakure, served as the bodyguard for the Fifth Mizukage. With his left eye transplanted with Byakugan, he could observe chakra and see from afar. Unfortunately, he was killed by the Ten Tails.

NO.5 Danzo Shimura: Danzo was the leader of Konoha's ANBU Root division. He possessed multiple Sharingans and had one eye replaced with a Sharingan. He died in battle against Sasuke.