1. Hinata Hizashi: Hinata Hizashi, founder of the Hyuga Clan, was powerful enough to rival Uchiha Madara. Hinata's resemblance to Hizashi indicates this regarding power during the Chunin Exam. The Byakugan, possessed by Hizashi and the Hyuga Clan, is considered the nemesis of the Sharingan.

2. Ashina Uzumaki: Ashina Uzumaki, leader of the Uzumaki Clan, had incredible vitality and powerful sealing jutsu.

The Uzumaki Clan, a branch of the Senju Clan, shared similarities with the Hyuga Clan. Ashina's strength was comparable to the First Hokage, who possessed the Sage of Six Paths' power and the Rinnegan.

3. Hashirama Senju: Hashirama Senju, leader of the Senju Clan, had superior strength to the Uchiha Clan. He used Wood Release to overpower Uchiha Madara, even with the assistance of the Nine-Tails. Defeating Madara was relatively easy for Hashirama due to Madara's incomplete mastery of the Mangekyou Sharingan at the time.

4. Tobirama Senju: Tobirama Senju, Hashirama's younger brother, and Second Hokage, possessed high combat intelligence and skill in developing ninjutsu. His techniques were designed to counter the Uchiha Clan, such as Flying Thunder God to counter the Sharingan and Eight Gates Asa Kujaku to break through Susano'o. He could battle Uchiha Madara.

5. Mito Uzumaki: Mito Uzumaki, wife of the First Hokage, was a powerful shinobi and Jinchuriki of the Nine-Tails. She possessed the Uzumaki Clan's bloodline legacy and had exceptionally powerful sealing jutsu. Uchiha Madara would struggle to defeat Mito without fully utilizing the powers of the Rinnegan.