In the Boruto series of Naruto, it is hinted that Uchiha Itachi's illness might be a result of a serious injury rather than an actual illness. In Boruto, the next generation of the Naruto universe, the Otsutsuki clan comes to Earth to collect the chakra of the tailed beasts.
One of the Otsutsuki members, Urashiki, plans to time-travel back to Naruto's childhood to steal the Nine-Tails chakra.
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