Six Paths of Pain: Itachi Uchiha's regular form is not far behind the strength of the Six Paths, and in their previous battle, Pain only managed to win by a small margin. Itachi, who obtained the power of the Six Paths, also implanted cells from Pain, which means he can easily overpower Pain. 

Six Paths of Tobi (Obito): Obito, who obtained the power of the Six Paths, also experienced a significant increase in strength.

At that time, his power was only second to Itachi, and his body also had cells from Pain, which made him immune to many of Pain's attacks. With the Kamui and the power of the Six Paths, he can defeat the First Hokage, Hashirama Senju. 

Six Paths of Naruto: Naruto's power also greatly increased after obtaining the Six Paths. Along with his own Sage Jutsu and the power of the Nine-Tails, he can defeat Pain in his Nine-Tails Sage Mode.

However, Naruto would not actively attack Pain. 

Six Paths of Sasuke: Sasuke's power also greatly increased after obtaining the Six Paths and the Rinnegan. The power of the Rinnegan cannot be underestimated. At this time, Sasuke's strength is similar to Itachi's, so he can also defeat the First Hokage, Hashirama Senju. 

Kushina Uzumaki (Naruto's mother): Kushina, the wife of the First Hokage, Hashirama Senju, may not have the same level of power as him. However, as a true man, he would never harm the woman he loves. So Kushina can also defeat Pain by making him listen and obey