1. Tsunade: Tsunade, a member of the Senju clan, possesses exceptional bloodline limits and vitality. Being part of the powerful Senju clan makes her superior to clans like Uchiha and Hyuga.
2. Itachi Uchiha: Itachi Uchiha is an extraordinary ninja prodigy with powerful visual abilities. Orochimaru desired Itachi's body to acquire his abilities, including the Mangekyou Sharingan and S-rank ninjutsu.
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