NO.1: Kimimaro Kaguya: Kimimaro comes from a family with a bloodline limit allowing them to control their bones, giving them strong defense. But he's terminally ill and wouldn't have survived long even if not killed. Orochimaru doesn't use his body for reincarnation.

NO.2: Shin: Shin and his brother Sai were taken into Root organization at a young age. They became emotionless machines for missions.

Terminal illness pushed Shin to sacrifice himself for Sai, believing he deserved a better life.

NO.3: Tsuki no Meijin: Tsuki no Meijin, a skilled swordsman, suffered from poor health and was ambushed and killed by Sand Ninja, despite his formidable strength.

NO.4: Itachi Uchiha: Itachi is known for silently carrying everything, even after death. He was terminally ill before his battle with Sasuke, coughing up blood.

Stress as a spy, guilt, and prolonged use of Mangekyou Sharingan may have caused his deteriorating health.

NO.5: Hashirama Senju: The fourth Hokage suffers from "chuunibyou" or "middle school second-year syndrome," evident not only in his speech and behavior but also in his jutsu names, like "Spiral Flash Super Round Dance Howl Three Style." The second Hokage mocks him for it.