1. Hundred Healing Technique: The Hundred Healing Technique is a secret technique of the Fifth Hokage, Tsunade, in the Naruto series. By releasing chakra from the forehead seal, it instantly heals wounds. Tsunade used this technique to break Madara Uchiha's Susanoo during their battle. Sakura can also use this technique to heal herself.

2. Superhuman Strength: Tsunade possesses superhuman strength that even Itachi Uchiha fears.

Her attacks are more devastating than A's high-speed movement. While Sasuke's Susanoo can defend against Tsunade's attacks, he can't withstand Sakura's continuous attacks.

3. Poison: Sakura is skilled in applying and understanding various poisons. Although Sasuke is immune to most poisons, Sakura's expertise allows her to administer poison to Sasuke using needles, making him vulnerable and leading to his defeat.

4. Teamwork with Kakashi: When Sasuke is weakened after his battle with Kabuto, Sakura could team up with Kakashi to increase their chances of defeating Sasuke. Even with his ample chakra, Sasuke wouldn't be guaranteed victory against both of them.

5. Convincing Naruto: Naruto is emotionally connected to Sasuke and wants to protect him. If Sakura can convince Naruto to help, along with Kakashi's assistance, defeating Sasuke would become easier, especially since Sasuke hasn't obtained Eternal Mangekyou Sharingan and Naruto has mastered Sage Mode and Rasenshuriken.