1. Zabuza Momochi: Kakashi and his team face their first antagonist, Zabuza Momochi. Zabuza is a renowned ninja. With Naruto and Sasuke's help, Kakashi defeats Zabuza.

2. Itachi Uchiha: Itachi is a highly talented shinobi who easily defeats Kakashi with his powerful Genjutsu.

3. Kakuzu: Kakuzu, a member of Akatsuki, is defeated by Naruto and Yamato, saving Kakashi and Team 10.

4. Orochimaru: Orochimaru's true power is unknown, but he is defeated by Itachi's Genjutsu. Kakashi is intimidated by Orochimaru's killing intent and loses to him.

5. Pain: Pain, the leader of Akatsuki, defeats Kakashi, but he is later revived by Naruto.