1. Danzo: Danzo is one of the top leaders of Konoha Village and the superior of Uchiha Itachi. Danzo threatens Itachi to carry out his mission, which leads to tragedy.
2. Uchiha Obito: Obito is the leader behind the Akatsuki organization, and Itachi knows his true identity.
3. Orochimaru: Orochimaru is Itachi's first partner in the Akatsuki organization, but he is not Itachi's opponent.
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