1. Uchiha Itachi: Itachi is a genius ninja who has achieved great feats, becoming an ANBU member despite being below the jounin level. However, he fell ill at a young age, leading to slower movements and weak physical strength. This ultimately caused his death.

2. Orochimaru: While Orochimaru is a legendary Sannin like Jiraiya, his physical condition is poor due to constantly experimenting on his body and changing bodies.

Although he found the White Snake Sage and had the chance to learn Senjutsu, his body couldn't handle the powerful natural energy, forcing him to give up.

3. Kimimaro: Orochimaru initially chose Kimimaro as a vessel but discovered he was already seriously ill, preventing the plan. Kimimaro's poor physical condition is evident through his reliance on medication to extend his life.

4. Tsukikage: Tsukikage is a jounin in Konoha and has a romantic relationship with Yūgao.

Although he suffers from illness, it doesn't seem severe based on his position and role as an examiner. However, his focus on training in swordsmanship implies a weakness in chakra level.

5. Onoki: Onoki is the third Tsuchikage, among the oldest ninjas alive during the Boruto series. He couldn't defeat the effects of aging and is not as strong as in his prime. Onoki was once known for challenging Madara Uchiha.