First: Tobirama Senju was a significant figure in Konoha, creating numerous ninjutsu and leaving behind a forbidden scroll that became a village treasure. During the first Great Ninja War, Tobirama found himself in a desperate situation when attacked by Kinkaku and Ginkaku from the Hidden Cloud Village. He acted as a decoy to stop the pursuers, sacrificing himself in the process. 

Second: Hiruzen Sarutobi, the Third Hokage, was a master of ninjutsu. During the Chunin Exams, he faced the First and Second Hokage, as well as Orochimaru, and knew he couldn't defeat Orochimaru.

Hiruzen used the Dead Demon Consuming Seal to seal away the First and Second Hokage and take Orochimaru's ninjutsu, successfully countering the attack. 

Third: Minato Namikaze, the Fourth Hokage, was a genius ninja who developed the Rasengan and the Flying Thunder God technique. When the Nine-Tails attacked Konoha, Minato defeated Obito but sacrificed himself to seal away the rampaging Nine-Tails. 

Fourth: Tsunade, the Fifth Hokage, was a strong medical ninja. She survived two desperate situations, one during Pain's attack on Konoha where Naruto saved her, and another during the Fourth Great Ninja War, where Orochimaru and the Hawk team rescued her from Madara Uchiha.

Fifth: Kakashi Hatake, also known as "Copy Ninja Kakashi," faced a desperate situation during Pain's attack on Konoha. He sacrificed himself to protect Choji but was later revived through the Outer Path technique.