1. Ōtsutsuki Clan: The Ōtsutsuki Clan is a major antagonist force in Boruto, alongside the villainous organization Kara. Three clan members have appeared, but Naruto and Sasuke have already defeated two of them. If more members appear, it will involve Kaguya's descendants on the moon. After previous battles, Kaguya's descendant Boruto has joined forces with Naruto.

2. Hyuga Hanabi: Hanabi, Hinata's sister, was kidnapped by Ōtsutsuki to awaken the Rinnegan as a child.

As a member of the Hyuga Clan and daughter of its leader, her Gentle Fist technique is strong. The Hyuga Clan has many unrevealed abilities, making Hanabi a potential powerhouse.

3. Uzumaki Himawari: Naruto's daughter, Himawari, possesses incredible power despite her young age. As a descendant of the Uzumaki and Hyuga clans, she can activate and deactivate her Byakugan and has super strength and acupoint manipulation talents.

Even Naruto cannot withstand her punch.

4. Mitsuki: Mitsuki is Orochimaru's artificially created son and inherits his talent. He can use various nature transformations and is skilled in Sage Mode, making the Ōtsutsuki Clan fear his potential.

5. Ichiraku Ramen Owner: The owner is rumored to be the most powerful person in the Naruto world, unaffected by the Ōtsutsuki Clan. He has a destructive Dojutsu but enjoys a peaceful life as he loves seeing others eat his ramen. However, the new generation prefers hamburgers, which may trigger the owner's return.