1. Chiyo, Gaara's grandmother and a skilled puppeteer, was also a medical ninja. She used a forbidden medical technique to revive Gaara by injecting her chakra into his body, sacrificing her own life in the process.
2. Nagato, the leader of the Akatsuki, had the Rinnegan implanted by Madara. He summoned the Gedo Statue but grew weak when his chakra was depleted, so he created the Six Paths of Pain to aid him.
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